陳培哲
教授

 
個人學經歷
 
EDUCATION
•M.D., Department of Medicine, College of Medicine, National Taiwan University(1981)
•Ph.D., Department of Pathology, Medical School,University of Pennsylvania(1984-1987)

POSITIONS HELD
•Professor, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan(1993-now)
•Chairman, Graduate Institute of Clinical Medicine, Medical College, National Taiwan University.(2002.8~2009.7)
•Director, Department of Medical Research National Taiwan University Hospital(2005~2009.7)
•Director, Hepatitis Research Center, National Taiwan University Hospital(2001-2003)
•University Professor of Medicine, Graduate Institute of Microbiology, Medical College, National Taiwan University.(1993~now)
•Professor of Medicine, Graduate Institute of Clinical Medicine, Medical College, National Taiwan University.(1986-1987)
•Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University(1987-1993)

HONORS:

•Member, Academia Sinica, since 2006
•International Research Scholar (2000-2005) of Infectious Disease, Howard Hughes Medical Institute, US
•National Outstanding Research Lectureship in Biomedical Science (1999), Academia Sinica, Taiwan
•Academic Award in Medical Science (1997), Ministry of Education,
•Science and Technology Award (1992), Executive Yuan, Taiwan
•SCBA (Society of Chinese Bioscientists in America) Hepatitis Research Award, 1992
•Outstanding Research Award; National Science Council, 1990-1996
•Academician, Academia Sinica, since 2006
•National Chair-Professor of Medicine, Ministry of Education, 2006-2009
 
研究專長
 

Hepatology, Gastroenterology, Internal Medicine, Molecular Virology, Cancer Research
RESEARCH INTERESTS:
The first is on molecular virology of hepatitis viruses. Current focus is on the hepatitis D virus(HDV). HDV is the simplest RNA virus that employs a very unique strategy for viral replication and expression. It uses a currently unknown cellularRNA polymerase and one viral protein, the small-hepatitis delta antigen for replication. We are interested in identifying this cellular polymerase by genetic and biochemical approaches. Viral small delta antigen is modified post-translationally (such as phosphorylation). These modifications play important role in ushering in different stage of viral life cycle. The mechanisms are under investigation.
The second is on the treatment of hepatitis B. Persistenthepatitis B has been very difficult to eradicate, though many current treatments can suppress HBV to a low level. Recently, stimulation of cellular immunity by therapeutic vaccine (especially DNA-based) becomes a promising approach. We set up a chronic hepatitis B animal model (in woodchucks) and would try the therapeutic vaccine.
The third part is related to liver cancer. Cancer is now considered as a genetic disease of somatic cells whose chromosomes are mutated because of carcinogen-induced injuries. Search for genes with mutations in liver cancer genomes will shed light on the transformation process. Genome research technique, including allele mapping, linkage analysis, large-scale sequencing and functional genomics will be applied. The laboratory welcome new blood showing strong interest and motivation in these fields.


實驗室可提供學習之實驗技術
病毒分離、一般分子生物技術、SNPs以及序列(在病毒及疾病)、蛋白質修飾之功能研究、B型肝炎之土撥鼠及轉殖基因動物模式。


 
五年內著作
 
SELECTED PUBLICATIONS:
1: Hsu CS, Wang CC, Wang PC, Lin HH, Tseng TC, Chen CH, Su WC, Liu CJ, Chen CL,Lai MY, Chen PJ, Chen DS, Kao JH. Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection. Hepatol Int. 2010 Jul 1;4(3):585-93. PubMed PMID: 21063481; PubMed Central PMCID: PMC2940010.
2: Yeo W, Chen PJ, Furuse J, Han KH, Hsu C, Lim HY, Moon H, Qin S, Yeoh EM, Ye SL. Eastern asian expert panel opinion: designing clinical trials of molecular targeted therapy for hepatocellular carcinoma. BMC Cancer. 2010 Nov 10;10:620. PubMed PMID: 21062497; PubMed Central PMCID: PMC2989333.
3: Kao JH, Chen PJ, Chen DS. Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects. Adv Cancer Res. 2010;108:21-72. PubMed PMID: 21034965.
4: Li CH, Chen PJ, Chu HC, Huang TY, Shih YL, Chang WK, Hsieh TY. Endoscopic submucosal dissection with the pulley method for early-stage gastric cancer (with). Gastrointest Endosc. 2010 Oct 26. [Epub ahead of print] PubMed PMID: 21030018.
5: Huang HH, Shih WL, Li YH, Wu CF, Chen PJ, Lin CL, Liu CJ, Liaw YF, Lin SM, Lee SD, Yu MW. Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon {gamma} signalling pathway. Gut. 2010 Oct 27. [Epub ahead of print] PubMed PMID: 20980339.
6: Pan YC, Li CF, Ko CY, Pan MH, Chen PJ, Tseng JT, Wu WC, Chang WC, Huang AM, Sterneck E, Wang JM. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells. Clin Cancer Res. 2010 Oct 22. [Epub ahead of print] PubMed PMID: 20971808.
7: Wu H, Tao J, Chen PJ, Shahab A, Ge W, Hart RP, Ruan X, Ruan Y, Sun YE. Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18161-6. Epub 2010 Oct 4. PubMed PMID: 20921386; PubMed Central PMCID: PMC2964235.
8: Chen KF, Tai WT, Liu TH, Huang HP, Lin YC, Shiau CW, Li PK, Chen PJ, Cheng AL. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through
the inhibition of STAT3. Clin Cancer Res. 2010 Nov 1;16(21):5189-99. Epub 2010 Sep 30. PubMed PMID: 20884624.
9: Lee MH, Yang HI, Lu SN, Jen CL, Yeh SH, Liu CJ, Chen PJ, You SL, Wang LY, Chen WJ, Chen CJ. Hepatitis C virus seromarkers and subsequent risk of hepatocellular
carcinoma: long-term predictors from a community-based cohort study. J Clin Oncol. 2010 Oct 20;28(30):4587-93. Epub 2010 Sep 20. PubMed PMID: 20855826.
10: Chen YJ, Liao CT, Chen PJ, Lee LY, Li YC, Chen IH, Wang HM, Chang JT, Chen LJ, Yen TC, Tang CY, Cheng AJ. Downregulation of Ches1 and other novel genes in
oral cancer cells chronically exposed to areca nut extract. Head Neck. 2010 May 19. [Epub ahead of print] PubMed PMID: 20848451.
11: Omata M, Lesmana LA, Tateishi R, Chen PJ, Lin SM, Yoshida H, Kudo M, Lee JM, Choi BI, Poon RT, Shiina S, Cheng AL, Jia JD, Obi S, Han KH, Jafri W, Chow P, Lim
SG, Chawla YK, Budihusodo U, Gani RA, Lesmana CR, Putranto TA, Liaw YF, Sarin SK. Asian Pacific Association for the Study of the Liver consensus recommendations on
hepatocellular carcinoma. Hepatol Int. 2010 Mar 18;4(2):439-74. PubMed PMID: 20827404; PubMed Central PMCID: PMC2900561.
12: Yang TS, Lu SN, Chao Y, Sheen IS, Lin CC, Wang TE, Chen SC, Wang JH, Liao LY, Thomson JA, Wang-Peng J, Chen PJ, Chen LT. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients. Br J Cancer. 2010 Sep 28;103(7):954-60. Epub 2010 Aug 31. PubMed PMID: 20808309; PubMed Central PMCID: PMC2965867.
13: Chen KF, Liu CY, Lin YC, Yu HC, Liu TH, Hou DR, Chen PJ, Cheng AL. CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene. 2010 Nov 25;29(47):6257-66. Epub 2010 Aug 23. PubMed PMID: 20729919.
14: Su TH, Chen PJ, Chen TC, Cheng HR, Li L, Lin KS, Kao JH, Chen DS, Liu CJ. The clinical significance of occult hepatitis B transfusion in Taiwan - a look-back study. Transfus Med. 2010 Aug 18. [Epub ahead of print] PubMed PMID: 20726954.
15: Huang KW, Wu HL, Lin HL, Liang PC, Chen PJ, Chen SH, Lee HI, Su PY, Wu WH, Lee PH, Hwang LH, Chen DS. Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14769-74. Epub 2010 Aug 2. PubMed PMID: 20679198; PubMed Central PMCID: PMC2930482.
16: Wang J, Chen PJ, Wang GJ, Keller L. Chromosome size differences may affect meiosis and genome size. Science. 2010 Jul 16;329(5989):293. PubMed PMID: 20647459.
17: Liu CH, Liang CC, Liu CJ, Lin JW, Chen SI, Hung PH, Tsai HB, Lai MY, Chen PJ, Chen DS, Kao JH. Pegylated interferon alfa-2a monotherapy for hemodialysis patients with acute hepatitis C. Clin Infect Dis. 2010 Sep 1;51(5):541-9. PubMed PMID: 20645865.
18: Yeh SH, Chen PJ. Gender disparity of hepatocellular carcinoma: the roles of sex hormones. Oncology. 2010 Jul;78 Suppl 1:172-9. Epub 2010 Jul 8. PubMed PMID:
20616601.
19: Chen PJ, Hsu JD, Han CP. Anti-cytokeratin CAM5.2 reagent (Becton Dickinson Biosciences) can detect CK 8, not CK8/18-Comment on "Sonographic findings in a patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor," J Clin Ultrasound 2010 Jan 20 [Epub ahead of print]. J Clin Ultrasound. 2010 Sep;38(7):384; author reply 385. PubMed PMID: 20623691.
20: Chen PJ, Furuse J, Han KH, Hsu C, Lim HY, Moon H, Qin S, Ye SL, Yeoh EM, Yeo W. Issues and controversies of hepatocellular carcinoma-targeted therapy clinical
trials in Asia: experts' opinion. Liver Int. 2010 Nov;30(10):1427-38. doi: 10.1111/j.1478-3231.2010.02292.x. PubMed PMID: 20557456.
21: Hsu CS, Liu CH, Liu CJ, Hsu SJ, Chen CL, Hwang JJ, Lai MY, Chen PJ, Chen DS, Kao JH. Association of metabolic profiles with hepatic fibrosis in chronic hepatitis C patients with genotype 1 or 2 infection. J Gastroenterol Hepatol. 2010 May;25(5):970-7. PubMed PMID: 20546452.
22: Liao CL, Tzeng SL, Hsu JD, Chen PJ, Han CP. BD (Becton, Dickinson and Company) Biosciences manufactures anticytokeratin CAM5.2, not CK8/18 monoclonal antibody. Pathol Int. 2010 May;60(5):417; author reply 418. PubMed PMID: 20518894.
23: Chen PJ, Liao TS, Hwang CH. Note: Simple hysteresis parameter inspector for camera module with liquid lens. Rev Sci Instrum. 2010 May;81(5):056105. PubMed PMID: 20515182.
24: Yu ML, Lee CM, Chuang WL, Lu SN, Dai CY, Huang JF, Lin ZY, Hu TH, Chen CH, Hung CH, Wang JH, Chen CL, Kao JH, Lai MY, Liu CH, Su TH, Wu SS, Liao LY, Kuo HT, Chao YC, Tung SY, Yang SS, Chen PJ, Liu CJ, Chen DS. HBsAg profiles in patients receiving peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. J Infect Dis. 2010 Jul 1;202(1):86-92.
PubMed PMID: 20482252.
25: Lin YJ, Huang LR, Yang HC, Tzeng HT, Hsu PN, Wu HL, Chen PJ, Chen DS. Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse
model. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9340-5. Epub 2010 May 3. PubMed PMID: 20439715; PubMed Central PMCID: PMC2889105.
26: Zhu P, Zheng SY, Mai MJ, Zhuang J, Chen JM, Chen XQ, Chen PJ, Wu RB. [Early and mid-term results after 17 mm St Jude Regent mechanical valve replacement in 44 patients with small aortic root]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):799-801. Chinese. PubMed PMID: 20423854.
27: Hsu CH, Shen YC, Lin ZZ, Chen PJ, Shao YY, Ding YH, Hsu C, Cheng AL. Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma. J Hepatol. 2010 Jul;53(1):126-31. Epub 2010 Mar 30. PubMed PMID: 20416968.
28: Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G. Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib. Neuro Oncol. 2010 May;12(5):466-72. Epub 2010 Jan 22. PubMed PMID: 20406897; PubMed Central PMCID: PMC2940624.
29: Yang HI, Sherman M, Su J, Chen PJ, Liaw YF, Iloeje UH, Chen CJ. Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. J Clin Oncol. 2010 May 10;28(14):2437-44. Epub 2010 Apr 5. PubMed
PMID: 20368541.
30: Liu CH, Liang CC, Liu CJ, Hsu SJ, Lin JW, Chen SI, Hung PH, Tsai HB, Lai MY, Chen PJ, Chen JH, Chen DS, Kao JH. The ratio of aminotransferase to platelets is a useful index for predicting hepatic fibrosis in hemodialysis patients with chronic hepatitis C. Kidney Int. 2010 Jul;78(1):103-9. Epub 2010 Mar 31. PubMed PMID: 20357753.
31: Ahn SH, Chan HL, Chen PJ, Cheng J, Goenka MK, Hou J, Lim SG, Omata M, Piratvisuth T, Xie Q, Yim HJ, Yuen MF; the APPROACH Working Group. Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions. Hepatol Int. 2010 Feb 20;4(1):386-395. PubMed PMID: 20305758; PubMed Central PMCID: PMC2836441.
32: Chiu YH, Wu CC, Lu YC, Chen PJ, Lee WY, Liu AY, Hsu CJ. Mutations in the OTOF gene in Taiwanese patients with auditory neuropathy. Audiol Neurootol. 2010;15(6):364-74. Epub 2010 Mar 11. PubMed PMID: 20224275.
33: Hsu HY, Chang MH, Ni YH, Chiang CL, Chen HL, Wu JF, Chen PJ. No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization. J Infect Dis. 2010 Apr 15;201(8):1192-200. PubMed PMID: 20210630.
34: Chiu SL, Chen SN, Chen YT, Chen PJ. Coats' Disease and Neovascular Glaucoma in a Child with Neurofibromatosis. J Pediatr Ophthalmol Strabismus. 2010 Feb 26:1-3. doi: 10.3928/01913913-20100218-02. [Epub ahead of print] PubMed PMID: 20210281.
35: Chen PJ, Hsu JD, Han CP. Anti-cytokeratin CAM 5.2 is specific for K8 and to a lesser extent for the closely related K7, but shows no reactivity with K18 or K19: comment on: "keratin expression in endocrine organs and their neoplasms" Endocr Pathol. 2009 Spring; 20(1):1-10. Endocr Pathol. 2010 Mar;21(1):69-70; author reply 71. PubMed PMID: 20174893.
36: Yu H, Yuan Q, Ge SX, Wang HY, Zhang YL, Chen QR, Zhang J, Chen PJ, Xia NS. Molecular and phylogenetic analyses suggest an additional hepatitis B virus genotype "I". PLoS One. 2010 Feb 19;5(2):e9297. PubMed PMID: 20174575; PubMed
Central PMCID: PMC2824819.
37: Hsu CH, Yang TS, Hsu C, Toh HC, Epstein RJ, Hsiao LT, Chen PJ, Lin ZZ, Chao TY, Cheng AL. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer. 2010 Mar 16;102(6):981-6. Epub 2010 Feb 16. PubMed PMID: 20160718; PubMed Central PMCID: PMC2844032.
38: Wang HY, Chien MH, Huang HP, Chang HC, Wu CC, Chen PJ, Chang MH, Chen DS. Distinct hepatitis B virus dynamics in the immunotolerant and early immunoclearance phases. J Virol. 2010 Apr;84(7):3454-63. Epub 2010 Jan 20. PubMed
PMID: 20089644; PubMed Central PMCID: PMC2838120.
39: Hsieh TH, Tseng TC, Liu CJ, Lai MY, Chen PJ, Hsieh HL, Chen DS, Kao JH. Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C. Antivir Ther. 2009;14(8):1157-63. PubMed PMID: 20032545.
40: Lee D, Chen PJ, Lee GB. The evolution of real-time PCR machines to real-time PCR chips. Biosens Bioelectron. 2010 Mar 15;25(7):1820-4. Epub 2009 Nov 27.Review. PubMed PMID: 20022485.
41: Jin BH, Xiao F, Chen B, Chen PJ, Xie LQ. Simultaneous determination of 42 organic chemicals in bottled water by combining C18 extraction disk with GC-MS and LC/MS/MS technique. J Water Health. 2010 Mar;8(1):116-25. PubMed PMID: 20009254.
42: Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Sheen LY. Rhizomes of Gastrodia elata B(L) possess antidepressant-like effect via monoamine modulation in subchronic animal model. Am J Chin Med. 2009;37(6):1113-24. PubMed PMID:
19938220.
43: Wu FT, Liang SY, Tsao KC, Huang CG, Lin CY, Lin JS, Su CY, Eng HL, Yang JY, Chen PJ, Yang CF. Hospital-based surveillance and molecular epidemiology of rotavirus infection in Taiwan, 2005-2007. Vaccine. 2009 Nov 20;27 Suppl 5:F50-4. PubMed PMID: 19931720.
44: Hong SY, Chen PJ. Phosphorylation of serine 177 of the small hepatitis delta antigen regulates viral antigenomic RNA replication by interacting with the processive RNA polymerase II. J Virol. 2010 Feb;84(3):1430-8. Epub 2009 Nov 18. Erratum in: J Virol. 2010 Mar;84(6):3131. PubMed PMID: 19923176; PubMed Central PMCID: PMC2812350.
45: Chen KF, Yu HC, Liu TH, Lee SS, Chen PJ, Cheng AL. Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol. 2010 Jan;52(1):88-95. Epub 2009 Oct 23. PubMed PMID: 19913321.
46: Chen JH, Chang PY, Ho CL, Chen PJ. Radiofrequency ablation as a palliative treatment of primary liver sarcoma in an inoperable patient with hepatitis C
virus-related cirrhosis. Onkologie. 2009 Sep;32(8-9):509-12. Epub 2009 Jul 31. PubMed PMID: 19745597.
47: Wu CC, Lu YC, Chen PJ, Liu AY, Hwu WL, Hsu CJ. Application of SNaPshot multiplex assays for simultaneous multigene mutation screening in patients with
idiopathic sensorineural hearing impairment. Laryngoscope. 2009 Dec;119(12):2411-6. PubMed PMID: 19718752.
48: Huang YW, Liao YT, Chen W, Chen CL, Hu JT, Liu CJ, Lai MY, Chen PJ, Chen DS, Yang SS, Kao JH. Vitamin D receptor gene polymorphisms and distinct clinical
phenotypes of hepatitis B carriers in Taiwan. Genes Immun. 2010 Jan;11(1):87-93. Epub 2009 Aug 20. PubMed PMID: 19693091.
49: Ko CH, Chen PJ, Chen SH, Chang FC, Lin FC, Chen KK. Extraction of chromium, copper, and arsenic from CCA-treated wood using biodegradable chelating agents.
Bioresour Technol. 2010 Mar;101(5):1528-31. Epub 2009 Aug 18. PubMed PMID:19692235.
50: Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS, Chen PJ. Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B. Hepatology. 2009 Nov;50(5):1392-402. PubMed PMID: 19670412.
51: Liu CJ, Chen PJ, Lai MY, Liu CH, Chen CL, Kao JH, Chen DS. High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection. Hepatol Int. 2009 Jun;3(2):364-70. Epub 2008 Dec 2. PubMed PMID: 19669362; PubMed Central PMCID: PMC2716759.
52: Liu CJ, Chen PJ, Chen DS. Dual chronic hepatitis B virus and hepatitis C virus infection. Hepatol Int. 2009 Dec;3(4):517-25. Epub 2009 Aug 8. PubMed PMID: 19669238; PubMed Central PMCID: PMC2790587.
53: Wu CC, Lu YC, Chen PJ, Yeh PL, Su YN, Hwu WL, Hsu CJ. Phenotypic analyses and mutation screening of the SLC26A4 and FOXI1 genes in 101 Taiwanese families with
bilateral nonsyndromic enlarged vestibular aqueduct (DFNB4) or Pendred syndrome. Audiol Neurootol. 2010;15(1):57-66. Epub 2009 Aug 1. PubMed PMID: 19648736.
54: Hsu C, Wei SC, Cheng AL, Chen PJ. Strategies to prevent hepatitis B virus reactivation in patients receiving immunosuppressive therapy. Hepatology. 2009
Aug;50(2):654-5. PubMed PMID: 19642167.
55: Hsu C, Cheng AL, Chen PJ. Lamivudine and hepatitis B reactivation. Ann Intern Med. 2009 Jul 21;151(2):141; author reply 141-2. PubMed PMID: 19620169.
56: Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance
performance in healthy volunteers. Chin J Integr Med. 2009 Jun;15(3):177-83. Epub 2009 Jul 2. PubMed PMID: 19568709.
57: Chien CY, Chen PJ, Hsin N. A small submucosal tumor in antrum. Gastroenterology. 2009 Aug;137(2):e1-2. Epub 2009 Jun 28. PubMed PMID: 19567240.
58: Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res. 2009 Jul 1;69(13):5296-300. Epub 2009 Jun 23. PubMed PMID: 19549889; PubMed Central PMCID: PMC2824172.
59: Hsu YL, Chia CC, Chen PJ, Huang SE, Huang SC, Kuo PL. Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial
system in human cervical carcinoma HeLa cells. Mol Nutr Food Res. 2009 Jul;53(7):826-35. PubMed PMID: 19536869.
60: Tseng TC, Liu CJ, Wang CC, Chen PJ, Lai MY, Chen DS, Kao JH. Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B
patients with high serum alanine aminotransferase levels. Antivir Ther. 2009;14(2):203-10. PubMed PMID: 19430095.
61: Chen CS, Chiou CT, Chen GS, Chen SC, Hu CY, Chi WK, Chu YD, Hwang LH, Chen PJ, Chen DS, Liaw SH, Chern JW. Structure-based discovery of triphenylmethane
derivatives as inhibitors of hepatitis C virus helicase. J Med Chem. 2009 May 14;52(9):2716-23. PubMed PMID: 19419203.
62: Chen ST, Ni YH, Chen PJ, Chen HL, Jeng YM, Lu MY, Wu JF, Hsu HY, Chang MH. Low viraemia at enrollment in children with chronic hepatitis C favours
spontaneous viral clearance. J Viral Hepat. 2009 Nov;16(11):796-801. Epub 2009
Apr 22. PubMed PMID: 19413696.
63: Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF. Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study. Eur J Hum Genet. 2009 Oct;17(10):1250-9. Epub 2009 Apr 1. PubMed PMID: 19337310.
64: Chou CH, Chen PJ, Jeng YM, Cheng AL, Huang LR, Cheng JC. Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1545-52. Epub 2009 Mar 26. PubMed PMID: 19327909.
65: Hsu CS, Liu CH, Liu CJ, Chen CL, Lai MY, Chen PJ, Chen DS, Kao JH. Factors affecting early viral load decline of Asian chronic hepatitis C patients receiving pegylated interferon plus ribavirin therapy. Antivir Ther. 2009;14(1):45-54. PubMed PMID: 19320236.
66: Liu CJ, Lee PH, Lin DY, Wu CC, Jeng LB, Lin PW, Mok KT, Lee WC, Yeh HZ, Ho MC, Yang SS, Lee CC, Yu MC, Hu RH, Peng CY, Lai KL, Chang SS, Chen PJ. Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage. J Hepatol. 2009 May;50(5):958-68. Epub 2009 Feb 15. PubMed PMID: 19303160.
67: Tseng LH, Storer B, Petersdorf E, Lin MT, Chien JW, Grogan BM, Malkki M, Chen PJ, Zhao LP, Martin PJ, Hansen JA. IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation. Transplantation. 2009 Mar 15;87(5):704-10. PubMed PMID: 19295315.
68: Wang YC, Yao NS, Chen PJ. Worms in the bowel: a cause of iron-deficiency anemia. Dig Liver Dis. 2010 Jul;42(7):524. Epub 2009 Mar 10. PubMed PMID: 19278907.
69: Hsu CS, Liu CH, Liu CJ, Wang CC, Chen CL, Lai MY, Chen PJ, Chen DS, Kao JH. Association of lipid profiles with hepatitis C viral load in chronic hepatitis C patients with genotype 1 or 2 infection. Am J Gastroenterol. 2009
Mar;104(3):598-604. Epub 2009 Feb 10. PubMed PMID: 19262519.
70: Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, Chen PJ, Cheng AL. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2009 Apr 24;284(17):11121-33. Epub 2009 Mar 4. PubMed PMID: 19261616; PubMed Central
PMCID: PMC2670117.
71: Huang WC, Huang LM, Chang IS, Chang LY, Chiang BL, Chen PJ, Wu MH, Lue HC, Lee CY; Kawasaki Disease Research Group. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics. 2009 Mar;123(3):e401-5. Epub 2009 Feb 23. PubMed PMID: 19237439.
72: Huang YW, Hu CY, Chen CL, Liao YT, Liu CJ, Lai MY, Chen PJ, Yang SS, Hu JT, Chen DS, Kao JH. Human leukocyte antigen-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus. J Med Virol. 2009 Apr;81(4):588-93. PubMed PMID: 19235869.
73: Yang WJ, Chang CJ, Yeh SH, Lin WH, Wang SH, Tsai TF, Chen DS, Chen PJ. Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways.
Hepatology. 2009 May;49(5):1515-24. PubMed PMID: 19205031.
74: Liu CJ, Jeng YM, Chen CL, Cheng HR, Chen PJ, Chen TC, Liu CH, Lai MY, Chen DS, Kao JH. Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B. J Infect Dis. 2009 Mar 1;199(5):742-9. PubMed PMID: 19199543.
75: Chang CC, Lee IL, Chen PJ, Wang HP, Hou MC, Lee CT, Chen YY, Cho YP, Lin JT. Endoscopic submucosal dissection for gastric epithelial tumors: a multicenter study in Taiwan. J Formos Med Assoc. 2009 Jan;108(1):38-44. PubMed PMID:19181606.
76: Chang JF, Chen PJ, Sze DY, Reid T, Bartlett D, Kirn DH, Liu TC. Oncolytic virotherapy for advanced liver tumours. J Cell Mol Med. 2009 Jul;13(7):1238-47.
Epub 2008 Oct 23. Review. PubMed PMID: 19175689.
77: Liu CH, Liang CC, Liu CJ, Tsai HB, Hung PH, Hsu SJ, Chen SI, Lin JW, Lai MY, Chen JH, Chen PJ, Chen DS, Kao JH. Pegylated interferon alpha-2a plus low-dose
ribavirin for the retreatment of dialysis chronic hepatitis C patients who relapsed from prior interferon monotherapy. Gut. 2009 Feb;58(2):314-6. PubMed
PMID: 19136527.
78: Wu CH, Yeh SH, Tsay YG, Shieh YH, Kao CL, Chen YS, Wang SH, Kuo TJ, Chen DS, Chen PJ. Glycogen synthase kinase-3 regulates the phosphorylation of severe acute
respiratory syndrome coronavirus nucleocapsid protein and viral replication. J Biol Chem. 2009 Feb 20;284(8):5229-39. Epub 2008 Dec 23. PubMed PMID: 19106108.
79: Liu CJ, Chuang WL, Lee CM, Yu ML, Lu SN, Wu SS, Liao LY, Chen CL, Kuo HT, Chao YC, Tung SY, Yang SS, Kao JH, Liu CH, Su WW, Lin CL, Jeng YM, Chen PJ, Chen DS. Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. Gastroenterology. 2009 Feb;136(2):496-504.e3. Epub 2008 Oct 29. PubMed PMID: 19084016.
80: Lee SC, Wu CT, Lee ST, Chen PJ. Cranioplasty using polymethyl methacrylate prostheses. J Clin Neurosci. 2009 Jan;16(1):56-63. PubMed PMID: 19046734.
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101: Chen PJ, Shih YL, Chu HC, Chang WK, Hsieh TY, Chao YC. A prospective trial of variable stiffness colonoscopes with different tip diameters in unsedated patients. Am J Gastroenterol. 2008 Jun;103(6):1365-71. Epub 2008 May 29. PubMed PMID: 18513270.
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103: Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, Wang LY, Sun CA, Lu SN, Chen DS, Chen CJ. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology. 2008 Jul;135(1):111-21. Epub 2008 Apr 4. PubMed PMID: 18505690.
104: Tsai WC, Chen PJ, Chao YC, Tsao YT. Chromoendoscopy with narrow-band imaging for early stage multifocal squamous cell carcinoma of the esophagus. J Clin
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105: Tseng TC, Liu CJ, Wang CC, Chen PJ, Lai MY, Kao JH, Chen DS. A higher alanine aminotransferase level correlates with earlier hepatitis B e antigen
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106: Liu CH, Hsu SJ, Liang CC, Tsai FC, Lin JW, Liu CJ, Yang PM, Lai MY, Chen PJ, Chen JH, Kao JH, Chen DS. Esophageal varices: noninvasive diagnosis with duplex
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107: Lu CY, Ni YH, Chiang BL, Chen PJ, Chang MH, Chang LY, Su IJ, Kuo HS, Huang LM, Chen DS, Lee CY. Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization. J Infect Dis. 2008 May 15;197(10):1419-26. PubMed PMID: 18444799.
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115: Lin GM, Lin JC, Chen PJ, Siu LK, Huang LY, Chang FY. Pan-drug resistant Acinetobacter baumannii bacteremia following endoscopic retrograde cholangiopancreatography. Am J Gastroenterol. 2008 Feb;103(2):498-9. PubMed PMID:
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120: Wu CC, Chen PJ, Chiu YH, Lu YC, Wu MC, Hsu CJ. Prospective mutation screening of three common deafness genes in a large Taiwanese Cohort with idiopathic bilateral sensorineural hearing impairment reveals a difference in the results between families from hospitals and those from rehabilitation facilities.
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126: Lo HF, Lin LL, Chen PJ, Chou WM. Site-directed mutagenesis of conserved Thr407, Asp433 and Met464 residues in small subunit of Escherichia coli
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144: Rosenfeldt EJ, Chen PJ, Kullman S, Linden KG. Destruction of estrogenic activity in water using UV advanced oxidation. Sci Total Environ. 2007 May 1;377(1):105-13. Epub 2007 Mar 7. PubMed PMID: 17346782.
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175: Ke WM, Li XJ, Yu LN, Lai J, Li XH, Gao ZL, Chen PJ. Etiological investigation of fatal liver failure during the course of chronic hepatitis B in southeast China. J Gastroenterol. 2006 Apr;41(4):347-51. PubMed PMID: 16741614.
176: Chen PJ, Shih CY, Tai YC. Design, fabrication and characterization of monolithic embedded parylene microchannels in silicon substrate. Lab Chip. 2006
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177: Huang YW, Lin CL, Chen PJ, Lai MY, Kao JH, Chen DS. Higher cut-off index value of immunoglobulin M antibody to hepatitis B core antigen in Taiwanese patients with hepatitis B. J Gastroenterol Hepatol. 2006 May;21(5):859-62. PubMed PMID: 16704536.
178: Lin LL, Chen PJ, Liu JS, Wang WC, Lo HF. Identification of glutamate residues important for catalytic activity or thermostability of a truncated
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179: Chen PJ, Wei CC, Wang C, Chen FW, Hsu YH, Chang MS. Promoter analysis of interleukin 19. Biochem Biophys Res Commun. 2006 Jun 9;344(3):713-20. Epub 2006 Apr 7. PubMed PMID: 16631120.
180: Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology. 2006 Apr;130(4):1153-68. PubMed PMID: 16618410.
181: Liu YC, Shen CY, Wu HS, Hsieh TY, Chan DC, Chen CJ, Yu JC, Yu CP, Harn HJ, Chen PJ, Hsieh CB, Chen TW, Hsu HM. Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas. World J Gastroenterol. 2006 Apr 14;12(14):2168-73. PubMed PMID: 16610016.
182: Liu CJ, Chen BF, Chen PJ, Lai MY, Huang WL, Kao JH, Chen DS. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis. 2006 May 1;193(9):1258-65. Epub
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183: Liu CJ, Lai MY, Chao YC, Liao LY, Yang SS, Hsiao TJ, Hsieh TY, Lin CL, Hu JT, Chen CL, Chen PJ, Kao JH, Chen DS. Interferon alpha-2b with and without ribavirin in the treatment of hepatitis B e antigen-positive chronic hepatitis B: a randomized study. Hepatology. 2006 Apr;43(4):742-9. Erratum in: Hepatology. 2006 May;43(5):1172. PubMed PMID: 16557544.
184: Shiah HS, Chao Y, Chen LT, Yao TJ, Huang JD, Chang JY, Chen PJ, Chuang TR, Chin YH, Whang-Peng J, Liu TW. Phase I and pharmacokinetic study of oral thalidomide in patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 2006 Nov;58(5):654-64. Epub 2006 Mar 7. PubMed PMID: 16520988.
185: Yeh SH, Wu DC, Tsai CY, Kuo TJ, Yu WC, Chang YS, Chen CL, Chang CF, Chen DS, Chen PJ. Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma. Clin Cancer Res. 2006 Feb 15;12(4):1097-108. PubMed PMID: 16489062.
186: Lee SY, Wu KM, Chen PJ, Sheu CY, Kuo CP, Wang TY, Wu CL. Intrathoracic tracheal obstruction caused by a carotid mycotic aneurysm in a patient with deep neck infection--a case report. Respiration. 2007;74(2):220-3. Epub 2005 Nov 7. PubMed PMID: 16484768.
187: Tseng LH, Lin MT, Shau WY, Lin WC, Chang FY, Chien KL, Hansen JA, Chen DS, Chen PJ. Correlation of interleukin-10 gene haplotype with hepatocellular
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188: Lu YT, Chen PJ, Sheu CY, Liu CL. Viral load and outcome in SARS infection: the role of personal protective equipment in the emergency department. J Emerg Med. 2006 Jan;30(1):7-15. PubMed PMID: 16434329.
189: Shih WL, Yu MW, Chen PJ, Yeh SH, Lo MT, Chang HC, Liaw YF, Lin SM, Liu CJ, Lee SD, Lin CL, Hsiao CK, Yang SY, Chen CJ. Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area. Oncogene. 2006 May 25;25(22):3219-24. PubMed PMID: 16407824.
190: Chang LY, Chiang BL, Kao CL, Wu MH, Chen PJ, Berkhout B, Yang HC, Huang LM; Kawasaki Disease Research Group. Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan. J Infect Dis. 2006 Jan 15;193(2):283-6. Epub 2005 Dec 2. PubMed PMID: 16362893.
191: Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS. Evolution of Hepatitis B virus in an acute hepatitis B patient co-infected with genotypes B and C. J Gen
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192: Pauli F, Liu Y, Kim YA, Chen PJ, Kim SK. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Development. 2006 Jan;133(2):287-95. Epub 2005 Dec 14. PubMed PMID: 16354718.
193: Hu CY, Wu CS, Lee CS, Wu CH, Tsai HF, Chen PJ, Hsu PN. HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C. Ann Rheum Dis. 2006 Jan;65(1):138-9. PubMed PMID: 16344504; PubMed Central PMCID: PMC1797994.
194: Lin CL, Kao JH, Chen BF, Chen PJ, Lai MY, Chen DS. Application of hepatitis B virus genotyping and phylogenetic analysis in intrafamilial transmission of
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195: Chen CC, Yang SY, Liu CJ, Lin CL, Liaw YF, Lin SM, Lee SD, Chen PJ, Chen CJ, Yu MW. Association of cytokine and DNA repair gene polymorphisms with hepatitis
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196: Liu CJ, Lo SC, Kao JH, Tseng PT, Lai MY, Ni YH, Yeh SH, Chen PJ, Chen DS. Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan. J Hepatol. 2006 Jan;44(1):39-46. Epub 2005 Jul 12. PubMed PMID: 16168517.
197: Lin MT, Storer B, Martin PJ, Tseng LH, Grogan B, Chen PJ, Zhao LP, Hansen JA. Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor beta genotype of donor. Blood. 2005 Dec 1;106(12):3995-4001. Epub 2005 Aug 18. PubMed PMID: 16109775;
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198: Chen PJ, Chen T. Measurements of acoustic dispersion on calcaneus using spilt spectrum processing technique. Med Eng Phys. 2006 Mar;28(2):187-93. Epub 2005 Jun 6. PubMed PMID: 15939657.
 
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