The institute was established in 1978 by professor Juei-Low Sung and other teaching faculties.

The goals of the institute is to train clinical doctor to have professional medical research skills, to promote the academic excellence of teachers and progress of whole aspects of clinical medicine research in clinical departments, and ultimately, to push forward the specifically, the mission of this institute is to cultivate outstanding clinical investigators or physician scientists who have adequate knowledge and skills of both clinical and laboratory research methodology.

Students of this institute are expected to have independent abilities and creative vision to find and solve important medical questions, and become the future leaders in biomedicine field. Until J 2003, there are 135 MD,Ph.D. and 30M.M.S